Adding a certain compound to certain chemical reactions, such as: 15862-33-6, 3-Bromo-2-hydroxy-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
Step 2: To a cooled (0-5 C.) mixture of 3-bromo-2-hydroxy-5-nitropyridine (47 g, 0.214 mol) and quinoline (13.7 g, 0.107 mol) was added POCl3 (26 mL, 0.278 mol) dropwise over ~10 min (the mixture was difficult to stir initially but became less viscous as the reaction progressed and the mixture warmed). After stirring at 120 C. for 3.5 h, the mixture was cooled to 100 C. and water (90 mL) was added. The resulting mixture was stirred vigorously while cooling to 0-5 C. The product was collected by filtration, washed with water and dried in vacuo at 45 C. to give 42 g of 3-bromo-2-chloro-5-nitropyridine (82% yield). 1H NMR (CD3OD) delta 9.19 (d, J=2.4 Hz, 1H), 8.93 (d, J=2.4 Hz, 1H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,15862-33-6, 3-Bromo-2-hydroxy-5-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; H. Lundbeck A/S; US2006/79524; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem