Reference of 955372-86-8, Adding some certain compound to certain chemical reactions, such as: 955372-86-8, name is 3-Bromo-5-fluoroisonicotinic acid,molecular formula is C6H3BrFNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 955372-86-8.
A mixture of 3-bromo-5-fluoroisonicotinic acid (5a, 1 .87 g, 8.5 mmol) and HATU (4.85 g, 12.75 mmol) in DMF (30 ml) was added DIEA (4.5 ml), the mixture was stirred at r.t for 20 minutes, then isonicotinimidamide (1 .236 g, 10.2 mmol) was added. Stirring was continued for another 15 hours at r.t. The reaction mixture was concentrated under reduced pressure. The light brown syrup crude mixture was then dissolved in DCM and purified by silica gel chromatography (eluted with 0-10% MeOH/solvent A, solvent A is mixture of 4 liter DCM and 8 ml of 7N ammonia solution in MeOH), fractions 66-80 were pooled and concentrated to afford the desired product 3-bromo-5-fluoro-N-(imino(pyridin-4- yl)methyl)isonicotinamide 5b (566 mg, 20.6%). 1 H NMR (500 MHz, DMSO-d6) delta 10.27 (s, 1 H), 10.09 (s, 1 H), 8.79 – 8.73 (m, 2H), 8.71 (s, 2H), 7.95 – 7.89 (m, 2H). LCMS (m/z [M+H]+): 323.0.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 955372-86-8, 3-Bromo-5-fluoroisonicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NOVARTIS AG; BEHNKE, Dirk; BERENSHTEYN, Frada; HAO, Xueshi; HOFFMAN, Timothy; JIN, Qihui; LACOSTE, Arnaud; LEE, Cameron; LIU, Jun; LIU, Yahu; MAIBAUM, Juergen Klaus; MO, Tingting; PAN, Jianfeng; QU, Xin; TCHORZ, Jan; XIE, Yun Feng; YAN, Shanshan; ZOU, Yefen; (564 pag.)WO2018/198077; (2018); A2;,
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