Adding a certain compound to certain chemical reactions, such as: 97944-43-9, 3-Bromo-5-methylpyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 3-Bromo-5-methylpyridin-4-amine, blongs to pyridine-derivatives compound. Application In Synthesis of 3-Bromo-5-methylpyridin-4-amine
step 2 A suspension of 98 and toluene (100 mL) was heated to 110 C until the solid dissolved. The the warm solution was added TEA (30 mL, 0.216 mmol) and acetic anhydride (20.4 mL, 22. 1g, 0.216 mmol) and the reaction was heated for 3 h. An additional 30 mL of AC2O was added after 3 h and an additional 30 mL of TEA was added after 6 h. The solution was concentrated in vacuo and the residue dissolved in EtOAc (500 mL) and was twice with H20 (200 mL). The aqueous extracts were reextracted twice with EtOAc (200 mL) and the combined EtOAc extracts were dried (MGS04), filtered and evaporated to afford a brown oil. The crude product was purified by flash chromatography over Si02 (0 to 20% EtOAc/hexane) to afford impure yellow oil which was subjected to a second flash chromatography over SI02 (20 to 50% EtOAc/hexane) to afford 99 (12.1 g).
The synthetic route of 97944-43-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/16892; (2005); A1;,
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