Reference of 799293-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 799293-85-9, name is 3-Bromothieno[3,2-c]pyridin-4-amine. A new synthetic method of this compound is introduced below.
To a solution of 3-bromo-thieno[2,3-c]pyridine-4-yl-amine (1.00 g, 4.38 mmol) in DMF (15 mL) was added NIS (1.08 g, 4.81 mmol). The resulting solution was stirred at room temperature overnight. Approximately half of the solvent was removed in vacuo and the resulting slurry was poured into sodium thiosulfate (5% solution in water, 100 mL). The resulting precipitate was collected and washed with water (2 x 30 mL) to afford 4-amino-7- biphenyl-3-yl-thieno[3,2-c]pyridine carboxylic acid as a tan solid (1.55 g, 4.38 mmol); RP- HPLC (Table 1, Method i) Rt 2.72 min; m/z: (M + H) + 357.1.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,799293-85-9, its application will become more common.
Reference:
Patent; ABBOTT LABORATORIES; WO2005/110410; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem