With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.20265-37-6, name is 3-Methoxy-2-nitropyridine, molecular formula is C6H6N2O3, molecular weight is 154.12, as common compound, the synthetic route is as follows.Recommanded Product: 3-Methoxy-2-nitropyridine
In a round bottom flask potassium tertiary butoxide (146 mg, 1.297 mmol) was taken under nitrogen atmosphere, anhydrous dimethylformamide (3 mL) was added and stirred at room temperature for 10 min. Then cooled to -40 C and 2-nitro-3-methoxypyridine(100 mg, 0.648 mmol) was added followed by dropwise addition of 2-chloro-propionic acid ethyl ester (0.0908 mL, 0.712 mmol) and stirred for 20 min. Then dilute HCI was added and stirred at room temperature for 10 min. Extracted in ethyl acetate, washed with water, dried over MgS0 , filtered and solvent was evaporated and finally purified by column chromatography to afford 2-(5-methoxy-6-nitro-pyridin-3-yl)-propionic acid ethyl ester (82 mg, 50%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,20265-37-6, 3-Methoxy-2-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; WO2013/13817; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem