The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Aminonicotinamide(SMILESS: O=C(N)C1=CN=C(N)C=C1,cas:329-89-5) is researched.Product Details of 75732-01-3. The article 《Human monocyte-derived dendritic cells produce millimolar concentrations of ros in phagosomes per second》 in relation to this compound, is published in Frontiers in Immunology. Let’s take a look at the latest research on this compound (cas:329-89-5).
Neutrophils kill ingested pathogens by the so-called oxidative burst, where reactive oxygen species (ROS) are produced in the lumen of phagosomes at very high rates (mM/s), although these rates can only be maintained for a short period (minutes). In contrast, dendritic cells produce ROS at much lower rates, but they can sustain production for much longer after pathogen uptake (hours). It is becoming increasingly clear that this slow but prolonged ROS production is essential for antigen cross-presentation to activate cytolytic T cells, and for shaping the repertoire of antigen fragments for presentation to helper T cells. Here, we quantified ROS production in human monocyte-derived dendritic cells by measuring the oxygen consumption rate during phagocytosis. Although a large variation in oxygen consumption and phagocytic capacity was present among individuals and cells, we estimate a ROS production rate of on average ∼0.5 mM/s per phagosome. Quant. microscopy approaches showed that ROS is produced within minutes after pathogen encounter at the nascent phagocytic cup. H2DCFDA measurements revealed that ROS production is sustained for at least ∼10 h after uptake. While ROS are produced by dendritic cells at an about 10-fold lower rate than by neutrophils, the net total ROS production is approx. similar. These are the first quant. estimates of ROS production by a cell capable of antigen cross-presentation. Our findings provide a quant. insight in how ROS affect dendritic cell function.
There is still a lot of research devoted to this compound(SMILES：O=C(N)C1=CN=C(N)C=C1)Application of 329-89-5, and with the development of science, more effects of this compound(329-89-5) can be discovered.