The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 380380-64-3, name is 5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 380380-64-3
Under nitrogen protection, 5.44 g of 3-fluoro-4-bromophenylcarbamic acid benzyl ester, 67 mL of dioxane and 5.76 g of hexabutylditin are added,Dichlorobistriphenylphosphine palladium 0.93g. Stir at 10 C to 15 C for 2 hours to 3 hours, filter and wash with dioxane to obtain a tributyltin intermediate in dioxane solution.The dioxane solution of the tributyltin intermediate is stirred at 35 C to 45 C, and 2-methyl-5- (5-bromopyridin-2-yl) tetrazolium 4.23g, potassium phosphate 2.09g, tetrakis ( Triphenylphosphine) palladium 0.083g, heated to 75 C-85 C and stirred for 3 hours to 4 hours. After cooling, filter 6g of diatomaceous earth, add 40mL of ethyl acetate and 15% saline (the mass concentration refers to the mass of sodium chloride as a percentage of the total mass of saline), and separate the organic phase Dry, concentrate in vacuum (temperature 35 C- 65 C , pressure -0.08MPa -0.1MPa), add ethyl acetate 26mL, heat to 70 C-75 C , stir for 0.5 hours 1 hour, cool to 0 C- 10 C, stir 1 Hours to 2 hours, filtered, rinsed with ethyl acetate 12mL three times, the wet product was dried in a vacuum (pressure -0.01MPa ~ -0.1MPa) drying oven at 45 C to 55 C for 8 hours to 12 hours, to obtain an off-white solid as tedizolid phosphate intermediate II 2.91g, total yield 42.9%, HPLC purity 97.18%.
With the rapid development of chemical substances, we look forward to future research findings about 380380-64-3.
Reference:
Patent; Shanghai Bozhi Yan Xin Pharmaceutical Co., Ltd.; Chen Jian; Liu Zhenfeng; Ying Shuhuan; (16 pag.)CN110804038; (2020); A;,
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