Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 38875-53-5, name is 5-Bromo-2,3-diaminopyridine. This compound has unique chemical properties. The synthetic route is as follows. 38875-53-5
General procedure: 136 (360mg, 2.92mmol) and disuccinimido carbonate (749mg, 2.92mmol) were dissolved in chloroform (5mL) and heated at reflux for 48h under N2. The reaction was then concentrated, and the residue dissolved in a 1:3 mixture of CyHex/EtOAc (200mL) and heated to reflux for 10min. The reaction was then cooled and the precipitate filtered and dried to obtain 145 as a solid (210mg, 48%).
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Reference:
Article; Blackmore, Timothy R.; Jacobson, Jonathan; Jarman, Kate E.; Lewin, Sharon R.; Nguyen, William; Purcell, Damian F.; Sabroux, Helene Jousset; Sleebs, Brad E.; European Journal of Medicinal Chemistry; vol. 195; (2020);,
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