Related Products of 19798-77-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.19798-77-7, name is 4-Amino-3-chloropyridine, molecular formula is C5H5ClN2, molecular weight is 128.56, as common compound, the synthetic route is as follows.
first step,Indole acetic acid (1.05 g)Was added to dichloromethane (20 mL) and stirred and stirred,EDCI (1.27 g) was added at room temperature,3-chloro-4-aminopyridine (0.85 g), DMAP (0.15 g),The reaction was stirred at room temperature for 3 h.Add deionized water (20 mL) for 10 min,The organic phase was stirred for 10 min with saturated brine (10 mL)The organic phase was removed at 40 C under reduced pressure to give the crude N- (3-chloropyridin-4-yl) -2- (1H-indol-3-yl) acetamide as a pale reddish brown oil.
Statistics shows that 19798-77-7 is playing an increasingly important role. we look forward to future research findings about 4-Amino-3-chloropyridine.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Ba Mingyu; Chen Minghua; Yang Ying; Zhu Chenggen; Chen Qing; Jiang Jiandong; Cao Yingli; Guo Qinglan; Zhang Chao; Lin Sheng; Tang Ke; Yang Yongchun; Guo Jiamei; (140 pag.)CN107149603; (2017); A;,
Pyridine – Wikipedia,
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