Reference of 1822-51-1, Adding some certain compound to certain chemical reactions, such as: 1822-51-1, name is 4-(Chloromethyl)pyridine hydrochloride,molecular formula is C6H7Cl2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1822-51-1.
A mixture of 4-hydroxylbenzaldehyde (2a) (1.2 g, 10 mmol), 4-(chloromethyl)pyridine hydrochloride (1.6 g, 10 mmol) and K2CO3 (4.2 g, 30 mmol) in dry DMF (12 mL) was stirred at 80 for 7 h. The cooled mixture was extracted with EtOAc (100 mL). The organic layer was washed with brine (2 × 100 mL) , dried (MgSO4) and concentrated to dryness. Yield = 1.3 g (61 %), tan crystals, recrystallised with methanol. m. p. = 102 – 104 (Lit. m. p. 57 – 58 ). TLC: petroleum ether-EtOAc 1: 3 v/v, Rf = 0.24 .1H NMR (DMSO-d6): delta 9.89 (s, 1H, CHO), 8.60 (dd, J = 1.6, 4.5 Hz, 2H, Ar), 7.91 (m, 2H, Ar), 7.47 (d, J = 6.3 Hz, 2H, Ar), 7.22 (dd, J = 1.8, 7Hz, 2H, Ar), 5.33 (s, 2H, CH2).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1822-51-1, 4-(Chloromethyl)pyridine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Taban, Ismail M.; Zhu, Jinge; DeLuca, Hector F.; Simons, Claire; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5629 – 5636;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem