Adding a certain compound to certain chemical reactions, such as: 24484-98-8, 4-Chloropyridine-2,3-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H6ClN3, blongs to pyridine-derivatives compound. COA of Formula: C5H6ClN3
Intermediate 8 (700mg, 4.876 mmol), polyphosphoric acid (5 g) and HOAc (442 mg, 7.31 mmol) are heated at 1500C for one hour. The reaction is dissolved in water, then NaOH is added until the pH is adjusted to pH=13. The solution is extracted with ethyl acetate (2×150 mL), washed with K2CO3 solution and brine, dried, and evaporated to give crude 7-chloro-2-methyl- 3H-imidazo[4,5-b]pyridine (9), which is used without purification. 1H NMR 400 MHz (CDCl3) delta 8.14 (s, IH), 6.55 (m, 2H), 2.69 (s, 3H); MS m/z 168.00 (M + 1).
The synthetic route of 24484-98-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IRM LLC; WO2008/144253; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem