As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 73455-13-7, name is 4,5-Dichloropicolinic acid, molecular formula is C6H3Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C6H3Cl2NO2
A mixture of 4,5-dichloropyridine-2-carboxylic acid (90 mg, 0.47mmol), HATU (250 mg, 0.66 mmol) and ethylamine (106 mg, 2.34 mmol) in DMF (3 ml_) was stirred at rt overnight. Water was added and the resulting solution was stirred at rt overnight. Precipitate was collected by filtration and dried to give the title compound (24 mg). 1 H NMR (500 MHz, DMSO- d6) 5 8.93 (br m, 1 H), 8.83 (s, 1 H), 8.17 (s, 1 H), 3.38 – 3.27 (m, 2H), 1.11 (t, J = 7.2 Hz, 3H).
With the rapid development of chemical substances, we look forward to future research findings about 73455-13-7.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; BELLENIE, Benjamin Richard; CARTER, Michael Keith; CHEUNG, Kwai Ming Jack; DAVIS, Owen Alexander; HOELDER, Swen; LLOYD, Matthew Garth; VARELA RODRIGUEZ, Ana; (381 pag.)WO2018/215801; (2018); A1;,
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