Synthetic Route of 483324-01-2 , The common heterocyclic compound, 483324-01-2, name is 2-Chloro-4-(pyridin-3-yl)pyrimidine, molecular formula is C9H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A 250 ml reactor, equipped with a mechanical stirrer and a reflux condenser, was charged with 2-chloro-4-(3-pyridyl)-pyrimidine (0.5 g, 2.6 mmol), 2-amino-4-nitrotoluene (0.5 g, 3.2 mmol), n-butanol (15 ml) and concentrated HCl (5 drops) and the mixture was refluxed for 38 hours. Then, the mixture was cooled, and 6 N NaOH was added to pH 8. The solvent was evaporated under reduced pressure and water (20 ml) was added to the residue, followed by extraction with dichloromethane (2×20 ml). The combined organic phase was concentrated to dryness to give the crude N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-pyrimidine-amine, which was purified by column chromatography to yield a product having 80% purity. The residue was re-slurried twice in methanol (2×2 ml) and in water (3 ml) and dried under reduced pressure
The synthetic route of 483324-01-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anli, Huang; Xing, Liu; Zelikovitch, Lior; Kaspi, Joseph; US2006/149061; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem