Application of 573762-62-6, Adding some certain compound to certain chemical reactions, such as: 573762-62-6, name is 5-Amino-3-(trifluoromethyl)picolinonitrile,molecular formula is C7H4F3N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 573762-62-6.
Compound 3 (0.50 g, 2.0 mmol) was added to a 25 mL two-necked flask. 3-trifluoromethyl-4 cyanoaniline (0.448 g, 2.40 mmol) and 6.5 mL N,N-dimethylacetamide, thiophosgene (0.28 ml, 3.20 mmol) was added dropwise to the solution, and the mixture was heated to 70 C for 24 h. After cooling to room temperature, 2 mL of methanol, 0.5 mL of concentrated hydrochloric acid and 2 mL of water were added, and the mixture was stirred under reflux for 2 h. After cooling to room temperature, ethyl acetate (10¡Á3 mL) was evaporated.The residue is purified by column chromatography to give compound 5, 0.286 g, pale yellow solid, yield 29.9%.
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Reference:
Patent; Changsha Zeda Pharmaceutical Technology Co., Ltd.; Chen Yongheng; Xu Guangyu; Zhou Wenqiang; (23 pag.)CN108976171; (2018); A;,
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