Synthetic Route of 936011-17-5, Adding some certain compound to certain chemical reactions, such as: 936011-17-5, name is 5-Bromo-2-methoxyisonicotinaldehyde,molecular formula is C7H6BrNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 936011-17-5.
5-Bromo-2-methoxypyridine-4-carbaldehyde (25 g, 115.5 mmol, 1 eq.) Was dissolved in 500 ml of dichloromethane, and the temperature was lowered to -78 C. Under the protection of nitrogen,Diethylaminosulfur trifluoride (74.5g, 462mmol, 4eq.) Was added dropwise.After the dropwise addition, the reaction was carried out at 21 C for 16 hours.After the reaction, drop the reaction drop into ice water,Make alkaline with saturated sodium bicarbonate solution.It was extracted with dichloromethane, and the organic phase was concentrated and then subjected to column chromatography to obtain 25.3 g of white solid 5-bromo-4- (difluoromethyl) -2-methoxypyridine in 92% yield.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 936011-17-5, 5-Bromo-2-methoxyisonicotinaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Ali Biological New Materials (Changzhou) Co., Ltd.; Shi Jianyun; Xu Yibo; Dai Hongsheng; Zhou Chao; (8 pag.)CN110734397; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem