Reference of 54916-66-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 54916-66-4, name is 5-Bromo-2-methoxynicotinic acid. A new synthetic method of this compound is introduced below.
5-Bromo-2-methoxynicotinic acid (15 g, 64.6 mmol, commercially available from, for example Apollo Scientific) was suspended in DCM (100 mL) and then oxalyl chloride (16.98 mL, 194 mmol) was added, followed by DMF (5.01 mL, 64.6 mmol) and the mixture was stirred for 18 h at rt. The solvent was evaporated in vacuo and the residue was redissolved in DCM (100 mL) and evaporated to dryness to give 5-bromo-2-methoxynicotinoyl chloride (16.33 g, 65.2 mmol, 101 % yield) which was used in the next step immediately. (0454) *H NMR (400 MHz, CDCI3) delta ppm 8.49 (d, J=2.7 Hz, 1 H) 8.44 (d, J=2.4 Hz, 1 H) 4.06 (s, 3 (0455) H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,54916-66-4, 5-Bromo-2-methoxynicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen, John; DEMONT, Emmanuel, Hubert; HARRISON, Lee, Andrew; HAYHOW, Thomas, George, Christopher; LINDON, Matthew, J.; PRESTON, Alexander, G.; SEAL, Jonathan, Thomas; WALL, Ian, David; WATSON, Robert, J.; WOOLVEN, James, Michael; (91 pag.)WO2017/60180; (2017); A1;,
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