Synthetic Route of 115170-40-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 115170-40-6, name is 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 125 Step 1: (2,3-dihydro-lH-pyrrolo[2,3-b]pyridin-5-yl)boronic acid and 5-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)-2,3-dihydro-lH-pyrrolo[2,3-b]pyridine To a stirred solution of 5-bromo-2,3-dihydro-lH-pyrrolo[2,3-b]pyridine (100 mg, 0.50 mmol) and 1 ,2-dimethoxyethane (4 mL) in a microwave vial equipped with a stirbar was added bis(pinacolato diborane) (175 mg, 0.65 mmol), potassium acetate (148 mg, 1.5 mmol) and 1,1′- bis(diphenylphosphino)ferrocene-palladium(II)dichloride (20.9 mg, 0.025 mmol). The mixture was purged with nitrogen gas for 5 min and the reaction mixture was stirred at 90 C for 5.5 h. The reaction mixture was filtered through a celite bed and washed with dichlorome thane (10 mL). The filtrate was concentrated to dryness in vacuo affording a crude mixture of (2,3-dihydro-lH- pyrrolo[2,3-b]pyridin-5-yl)boronic acid and 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2,3- dihydro-lH-pyrrolo[2,3-b]pyridine used for the next step without any further purification.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 115170-40-6, 5-Bromo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; HUESTIS, Malcolm; KELLAR, Terry; PATEL, Snahel; SHORE, Daniel; SIU, Michael; (260 pag.)WO2016/142310; (2016); A1;,
Pyridine – Wikipedia,
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