At the same time, in my other blogs, there are other synthetic methods of this type of compound,1480-65-5, 5-Chloro-2-fluoropyridine, and friends who are interested can also refer to it.
Synthetic Route of 1480-65-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1480-65-5, name is 5-Chloro-2-fluoropyridine. A new synthetic method of this compound is introduced below.
Example 116 EPO (5R)-7-(5-ChIoropyridin-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-2,7-diazaspiro[4.5]decan-l-one A mixture of (5R)-2-(tetrahydro-2H-pyran-4-yl)-2,7-diazaspiro[4.5]decan-l-one hydrochloride (29.4 mg, 0.000107 mol, this compound was prepared by using procedures analogous to those described for the synthesis of example 1, steps 1-5), 5-chloro-2-fluoropyridine (17 mg, 0.00013 mol) and potassium carbonate (0.029 mL, 0.00032 mol) in N,N-dimethylformamide (0.6 mL, 0.008 mol) was heated at 120 0C for 5 h. The crude product was purified by prep-HPLC to afford the desired product. LC-MS: 350.2 (M+H)+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1480-65-5, 5-Chloro-2-fluoropyridine, and friends who are interested can also refer to it.
Reference:
Patent; INCYTE CORPORATION; WO2006/53024; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem