Analyzing the synthesis route of 5-Iodo-2-(trifluoromethyl)pyridine

The synthetic route of 873107-98-3 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 873107-98-3, 5-Iodo-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 5-Iodo-2-(trifluoromethyl)pyridine, blongs to pyridine-derivatives compound. Safety of 5-Iodo-2-(trifluoromethyl)pyridine

A mixture of 5-iodo-2-(trifluoromethyl)pyridine (0.1 1 g, 0.39 mmol), Intermediate 21 (100 mg, 0.33 mmol), Pd2(dba)3 (15 mg, 0.02 mmol), xantphos (9.4 mg, 0.02 mmol) and Cs2C03 (0.21 g, 0.65 mmol) in anhydrous dioxane (10 mL) was heated at 100C for 19 hrs. The reaction mixture was cooled to ambient temperature, concentrated in vacuo and the crude product purified by chromatography on the Biotage Companion (40 g column, 0 to 60%, EtOAc in isohexane) and the further purified by chromatography on the Biotage Companion (12 g column, 0 to 5% methanol in DCM) to afford the title compound as a solid (45 mg). LCMS (Method A): Two peaks at 2.25 min and 2.49 min, 453/455 [M+H]+. 1H NMR (400 MHz, DMSO-d6) 8.17-8.10 (m, 1 .59 H), 8.06 (s, 0.91 H), 8.03-7.95 (m, 0.32 H), 7.95-7.86 (m, 0.62 H), 7.83 (d, 0.08 H), 7.79 (d, 0.32 H), 7.74-7.64 (m, 0.81 H), 7.54 (d, 0.67 H), 7.50-7.40 (m, 1 .07 H), 7.36 (d, 0.12 H), 7.16-7.07 (m, 1 .03 H), 6.92-6.81 (m, 0.84 H), 6.81 -6.72 (m, 0.46 H), 6.70 (bdd, 0.08 H), 6.40 (bm, 0.08 H), 4.62 (bm, 0.32 H), 4.43 (bm, 0.15 H), 3.58 (bm, 0.09 H), 3.35 (bm, 0.52 H), 3.19 (bm, 0.42 H), 3.01 (bm, 0.08 H), 2.88 (s, 2.39 H), 2.83 (s, 0.62 H), 2.68 (bm, 2.12 H), 1.78- 1 .52 (bm, 1.21 H), 1.35 (bm, 0.15 H), 0.97 (m, 1.98 H), 0.89 (t, 0.39 H), 0.51 (t, 0.56 H).

The synthetic route of 873107-98-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; C4X DISCOVERY LIMITED; BLANEY, Emma Louise; MARTIN, Barrie Phillip; NOWAK, Thorsten; WATSON, Martin John; (212 pag.)WO2016/34882; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem