Synthetic Route of 918511-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 918511-92-9, name is 5-(Pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine, molecular formula is C12H9N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To 3-nitrobenzaldehyde (534, 1.08 g, 7.17 mmol) in methanol (34 niL) was added 5- pyridin-3-yl-lH-pyrrolo[2,3-b]pyridme (89, 1.08 g, 5.52 mmol, prepared as described in Example 17) and potassium hydroxide (1.55 g, 27.6 mmol). The reaction was stirred at room temperature for four hours. The reaction was poured into water and extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated. The mixture was purified by silica gel column chromatography eluting with 4% methanol in dichloromethane to provide two different compounds, a white solid (P-1399, R = H, 1.20 g, 63%) MS(ESI) [MMf]+ = 347.2, and a light yellow solid (535, R = Me, 0.434 g, 22%).
According to the analysis of related databases, 918511-92-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PLEXXIKON, INC.; WO2007/2325; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem