Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5349-17-7, name is 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide
[0332] 7V-(3-Fluorophenyl)-4-(4-pyridinyl)-l,3-thiazol-2-amine (121). Reaction of bromoketone hydrobromide 1 (0.65 g, 2.3 mmol) and 3-fluorophenylthiourea (120) (0.39 g, 2.3 mmol) gave amine 121 (0.45 g, 71%) as a white powder: mp (EtOAc/pet. ether) 229-230 0C; 1H NMR delta 10.59 (br s, 1 H, NH), 8.63 (dd, J = 4.5, 1.6 Hz, 2 H, H-2′, H-6′), 7.35 (dd, J= 4.5, 1.6 Hz, 2 H, H-3′, H-5′), 7.28-7.31 (m, 1 H, H-2″), 7.76 (s, 1 H, H-5), 7.34-7.41 (m, 2 H, H-5″, H-6″), 6.77-6.84 (m, 1 H, H-4″); 13C NMR delta 163.0, 162.4 (d, J= 240 Hz), 150.1 (2), 147.6, 142.4 (d, J = 11 Hz), 140.8, 130.5 (d, J= 10 Hz), 119.8 (2), 112.7 (d, J= 2 Hz), 108.0, 107.5 (d, J= 21 Hz), 103.5 (d, J= 26 Hz). Anal, calcd for Ci4Hi0FN3S: C, 61.98; H, 3.72; N, 15.49. Found: C, 61.91; H, 3.79; N, 15.20%.
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Reference:
Patent; THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY; AUCKLAND UNISERVICES LIMITED; WO2009/114552; (2009); A1;,
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