5446-92-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5446-92-4, name is 2-Methoxy-5-nitropyridine. A new synthetic method of this compound is introduced below.
[0238] A mixture of 2-methoxy-5-nitropyridine (5.0 g,32.4 mmol) in HOAc (50 ml) was added iron powder (5 g,89.53 mmol). After the mixture was heated to 60 C. for 2 h,the mixture was filtered through celite, and the filtered cakewas washed with HOAc and then water. The filtrate wasconcentrate and the residue was neutralized with saturatedNaHC03 solution, the aqueous phase was extracted withDCM (1 00 ml), and insoluble materials were removed byfiltration. After the aqueous phase was extracted with DCM(100 mlx4), the combined organic phase was washed withbrine and concentrated to afford crude product, which waspurified by silica gel colunm chromatography (2% MeOH inDCM) to afford compound 22 (3.5 g, yield 86%) as a brownoil[0239] m/z: [M+Ht 125.2
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5446-92-4, 2-Methoxy-5-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Gao, Daxin; Yang, Heping; Yu, Yajun; US2014/329800; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem