Related Products of 5470-22-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5470-22-4, name is 4-Chloropicolinic acid, molecular formula is C6H4ClNO2, molecular weight is 157.55, as common compound, the synthetic route is as follows.
A solution of 4-chloropicolinic acid (0.78 g, 5 mmol) in aqueous dimethylamine (40%, 10 ml) was stirred at 100 C for 5 h in a sealed tube. The resulting solution was concentrated in vacuo, then dissolved in EtOAc (50 ml) and washed with saturated aqueous NaHCO3 (50 ml) twice. The organic phase was dried over MgSO4 and evaporated in vacuo to afford compound 16 (0.79 g, 95%). 1H NMR (DMSO-d6, 400 MHz): delta 8.20 (d, J=7.48 Hz, 1H), 7.43 (d, J=2.98 Hz, 1H), 7.10 (dd, J1=3.01 Hz, J2=7.53 Hz, 1H), 3.27 (s, 6H). ESI-HRMS: m/z calcd for C8H10N2O2 [M+H]+ 189.0634 found 189.0638.
The chemical industry reduces the impact on the environment during synthesis 5470-22-4, I believe this compound will play a more active role in future production and life.
Reference:
Article; Lu, Chaocao; Htan, Bu; Fu, Shitao; Ma, Chunmiao; Gan, Quan; Tetrahedron; vol. 75; 30; (2019); p. 4010 – 4016;,
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