Adding a certain compound to certain chemical reactions, such as: 56057-19-3, 6-Chloro-5-nitro-2-picoline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 56057-19-3, blongs to pyridine-derivatives compound. Product Details of 56057-19-3
Step 1 2-Chloro-3-nitro-6-picoline-N-oxide 2-Chloro-3-nitro-6-picoline (2 g, 11.6 mmol) was added to an ice cooled mixture of trifluoroacetic acid (6 mL) and 30% peracetic acid in acetic acid (6 mL). The mixture was allowed to warm to room temperature over 30 minutes and was heated in a 60 C. oil bath for 5 hours. The mixture was partitioned between methylene chloride (100 mL) and water (50 mL). The pH was adjusted to 8 with 2.5 N sodium hydroxide and the aqueous layer was extracted with more methylene chloride (2*50 mL). The combined methylene chloride layers were dried with magnesium sulfate, filtered and evaporated to give the title compound as a white solid (1.6g). 1 H NMR (CDCl3, 300 MHz) delta2.62(s, Me), 7.35 (d, ArH), 7.66 (d, ArH).
The synthetic route of 56057-19-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Merck & Co., Inc.; US5498777; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem