Application of 582303-10-4 ,Some common heterocyclic compound, 582303-10-4, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of tri-n-butylphosphine (7.10 mL) , (2,6- dimethylpyridin-3-yl) methanol (3.00 g) , ethyl ( 6-hydroxy-l- benzothiophen-3-yl) acetate (5.43 g) and THF (150 mL) was added ADDP (7.17 g) at room temperature. The mixture was stirred at room temperature under nitrogen atmosphere overnight. The mixture was concentrated. To the residue was added IPE and the precipitate was filtered off. The filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (7.74 g) XH NMR (300 MHz, CDC13) 61.19-1.32 (3H, m) , 2.54 (3H, s), 2.58 (3H, s), 3.81 (2H, d, J = 0.8 Hz), 4.17 (2H, q, J = 7.2 Hz), 5.08 (2H, s), 7.02 (1H, d, J = 7.9 Hz), 7.08 (1H, dd, J = 8.7, 2.3 Hz), 7.19 (1H, t, J = 0.9 Hz), 7.39 (1H, d, J = 2.3 Hz), 7.61 (1H, d, J = 7.6 Hz), 7.67 (1H, d, J = 8.7 Hz).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 582303-10-4, (2,6-Dimethylpyridin-3-yl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKAKURA, Nobuyuki; BANNO, Yoshihiro; TERAO, Yoshito; OCHIDA, Atsuko; MORIMOTO, Sachie; KITAMURA, Shuji; TOMATA, Yoshihide; YASUMA, Tsuneo; IKOMA, Minoru; MASUDA, Kei; WO2013/125732; (2013); A1;,
Pyridine – Wikipedia,
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