Adding a certain compound to certain chemical reactions, such as: 1207557-36-5, 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 1207557-36-5, blongs to pyridine-derivatives compound. Recommanded Product: 1207557-36-5
To a solution of 6-bromo-4-methoxypyrazolo[i,5-a]pyridine (Intermediate P1; 2.00g, 227.1 mmol) and 1 -methyl-4- (4,4, 5,5-tetramethyl- 1,3 ,2-dioxaborolan-2-yl)- 1H-pyrazole (2.02 g, 208.1 mmol) in dioxane (10 mL) was added 2 M Na2CO3(aq) (8.1 mL, 17.6 mmol) and Pd(PPh3)4 (4.584 g, 3.967 mmol). The reaction mixture was purged with nitrogen for 2 mm, sealed and heated at 90 C for 4 h. After cooling to ambient temperature, the reaction mixture was diluted with water (50 mL) and stirred for 30 mm. The resulting suspension was vacuum filtered, rinsed sequentially with water (2 x 20 mL) and Et20 (2 x 10 mL) to yield the crude title compound, which was used in the next step without further purification. MS (apci), m/z = 229.1 (M+H).
The synthetic route of 1207557-36-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARRAY BIOPHARMA, INC.; ANDREWS, Steven W.; BLAKE, James F.; CHICARELLI, Mark J.; GOLOS, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; (594 pag.)WO2017/11776; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem