Electric Literature of 137129-98-7, Adding some certain compound to certain chemical reactions, such as: 137129-98-7, name is 6-Chloro-2-methylnicotinic acid,molecular formula is C7H6ClNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 137129-98-7.
To stirred solution of 6-chloro-2-methyl-pyridine-3-carboxylic acid in ie t-butanol (15mL) was added Et3N (1 .85mL, 13.3mmol) and DPPA (2.86mL, 3.3mmol) and the reaction heated at 90C for 2 hours. The reaction was allowed to cool to room temperature overnight, diluted with water (50ml_) and extracted with EtOAc (3 x 30ml_). The combined organic extracts were washed with water (15ml_), brine (15ml_), dried over MgSC>4 and evaporated to dryness under reduced pressure. The residue was purified by flash chromatography over S1O2 using a gradient of 5-50% EtOAc/isohexane as eluent to give the desired product (1.75g, 71 %) as a white solid. 1H NMR (400 MHz, CDCy delta 8.18 (br. d, 1 H), 7.16 (d, 1 H), 6.26 (br.d, 1 H), 2.48 (s, 3H), 1 .52 (s, 9H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 137129-98-7, 6-Chloro-2-methylnicotinic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; CARTER, Neil, Brian; BRIGGS, Emma; KITSIOU, Christiana; LING, Kenneth; MORRIS, James, Alan; TATE, Joseph, Andrew; WAILES, Jeffrey, Steven; WILLIAMS, John; (94 pag.)WO2017/162524; (2017); A1;,
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