Related Products of 93683-65-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 93683-65-9, name is 6-Chloro-3-nitropicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Generalprocedure. A solution of 6-chloro-2-cyano-3-nitropyridine (1 equiv) in toluene or dioxane/water (see compound description) was degassed with argon and subsequently, the corresponding aryl boronic acid (1.2equiv), Pd(PPh3)4 (0.02 equiv) and K2CO3 (2 equiv) were added. The mixture was degassed a second time, filled with argon and stirred at 95 C overnight. After completion of the reaction as monitored by TLC,the volatiles were evaporated to dryness and the crude residue was diluted with EtOAc (20 mL) and washed with water (2×20 mL). The organic layer was dried over anhydrous Na2SO4 and concentrated invacuo. The resulting residue was purified by silica gel flash chromatography, yielding the corresponding 6-aryl-3-nitropyridine-2-carbonitrile. The following compounds were made according to this procedure.
According to the analysis of related databases, 93683-65-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; De Jonghe, Steven; Einav, Shirit; Froeyen, Mathy; Herdewijn, Piet; Martinez-Gualda, Belen; Pu, Szu-Yuan; Bioorganic and medicinal chemistry; vol. 28; 1; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem