Application of 898746-42-4 ,Some common heterocyclic compound, 898746-42-4, molecular formula is C7H5FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 6-fluoro-1H-pyrrolo[2,3-b]pyridine (2.50 g, 18.36 mmol) in DMF (50 mL) was added a solution of bromine (3.20 g, 20.00 mmol) in DMF (20 mL) at 0 C . After the addition, the mixture was stirred at rt for 2 h. To the mixture was added water (100 mL), then there was a lot of solid precipitated out. The mixture was filtered under reduced pressure, and the filter cake was washed with water (30 mL) for two times and then dried in vacuo at 60 C for 24 h to give the title compound as a white solid (3.44 g, 87%).MS (ESI, pos. ion) m/z: 217.1 [M+H]+1H NMR (400 MHz, DMSO-d6) (ppm): 12.20 (s, 1H), 8.04 – 7.95 (m, 1H), 7.67 (d, J = 2.5 Hz, 1H), 6.94 (t, J = 9.7 Hz, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,898746-42-4, its application will become more common.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; TANG, Changhua; LIN, Xiaohong; YIN, Junjun; YI, Kai; (270 pag.)WO2017/97234; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem