Electric Literature of 1190320-33-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1190320-33-2, name is 6-Fluoro-1H-pyrrolo[3,2-b]pyridine, molecular formula is C7H5FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
step 4: To a solution of 6-fluoro-lH-pyrrolo[3,2-b]pyridine (9.52 g, 70 mmol) in THF (150 mL) at 0 C was added NaH (60%> in mineral oil, 2.02 g, 84 mmol) in three portions. After stirring at RT for 30 min, the mixture was cooled to 0 C and p-TsCl (14.7 g, 77 mmol) was added. The reaction mixture was stirred for 3 h and the temperature was slowly raised to RT. The reaction mixture was poured into ice- cold water and a precipitate was formed. The precipitate was collected by filtration. The crude product was purified by S1O2 chromatography eluting with DCM to afford 18 g (80%) of 6-fluoro-l -tosyl-lH- pyrrolo[3,2-b]pyridine as a solid. MS (ESI): m/z = 291.1 [M+l]+.
According to the analysis of related databases, 1190320-33-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; ALIAGAS-MARTIN, Ignacio; CRAWFORD, James John; MATHIEU, Simon; RUDOLPH, Joachim; LEE, Wendy; WO2013/92940; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem