Application of 60010-03-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60010-03-9, name is 2,6-Dichloro-4-methyl-3-nitropyridine. A new synthetic method of this compound is introduced below.
6-chloro-2-(4,4-difluoro-1 -piperidyl)-4-methyl-3-nitro-pyridine (Intermediate com- pound)A solution of 2,6-dichloro-4-methyl-3-nitropyhdine (4.5g;21.7 mmol), 4,4- Difluoropiperidine (3.97g; 1.1 eq) and TEA (12ml; ca.4eq) in MeCN (30ml) was stirred at rt over night after which the reaction mixture was quenched with sat.NaHCOs(aq) solution and extracted with EtOAc (3x 5OmL). The combined or- ganic. were washed with brine, dried over Na2SO4(s), filtered and evaporated in vacuo to give 6.27g yellow solid (90% pure title compound)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60010-03-9, its application will become more common.
Reference:
Patent; NEUROSEARCH A/S; BROWN, William, Dalby; JESSEN, Carsten; MATTSSON, Cecilia; SOTT, Richard; STRØBAeK, Dorte; WO2010/122064; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem