With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62135-58-4, name is Ethyl [1,2,4]triazolo[1,5-a]pyridine-2-carboxylate, molecular formula is C9H9N3O2, molecular weight is 191.19, as common compound, the synthetic route is as follows.Recommanded Product: Ethyl [1,2,4]triazolo[1,5-a]pyridine-2-carboxylate
a [1,2,4]Triazolo[1,5-a]pyridin-2-ylmethanol To ethyl [1,2,4]triazolo[1,5-a]pyridine-2-carboxylate (prepared as described in J. Chem. Soc., Perkin Trans. 1, 1976, 2166) (0.67 g, 3.5 mmol) in THF (10 ml) was added lithium borohydride (78 mg, 3.6 mmol) and the mixture was stirred at room temperature under nitrogen overnight. The solvent was removed in vacuo and the residue was purified by flash chromatography on silica gel, eluding with 2.5 to 5% methanol in dichloromethane. The resultant solid was recrystallized from ethyl acetate, yielding [1,2,4]triazolo[1,5-a]pyridin-2-ylmethanol as a white solid (0.054 g).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,62135-58-4, Ethyl [1,2,4]triazolo[1,5-a]pyridine-2-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; Merck Sharp & Dohme Ltd.; US6476030; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem