As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62150-47-4, name is Ethyl 4-bromopicolinate, molecular formula is C8H8BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C8H8BrNO2
At a temperature of less than 40 C,Dissolve 1300 g of Cpd 2 in 7 L of ethanol.Add 400g of sodium borohydride in batches,Stir at room temperature overnight;2N hydrochloric acid was added dropwise at a temperature of less than 20 C to adjust the pH to weakly alkaline,Rotate most of the ethanol,add water,Adjusted to strong alkaline with potassium carbonate,Extracted with ethyl acetate (EA),Wash the product to the aqueous phase with 1N hydrochloric acid.Extracted with EA,The aqueous phase is added with potassium carbonate to adjust to strong alkalinity,EA extraction, sodium chloride washing,Dry over anhydrous sodium sulfate and spin dry.Through the column, 4-bromopyridine-2-methanol (Cpd 3) 650 g was obtained. The yield was 62%.
With the rapid development of chemical substances, we look forward to future research findings about 62150-47-4.
Reference:
Patent; Tianjin Quan He Cheng Science And Technology Co., Ltd.; Song Yanmin; Wan Jiaqiang; Li Weide; (11 pag.)CN108516953; (2018); A;,
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