Adding a certain compound to certain chemical reactions, such as: 6332-56-5, 3-Nitropyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 3-Nitropyridin-2(1H)-one, blongs to pyridine-derivatives compound. Safety of 3-Nitropyridin-2(1H)-one
(1a-1) To a solution of 2-hydroxy-3-nitropyridine (Aldrich, 3.0 mmol, 420 mg) in 1,4-dioxane (20 mL), were added 4-fluorophenyl boronic acid (Combi-block, 6.0 mmol, 840 mg), copper(II) acetate (Aldrich, 4.5 mmol, 815 mg) and pyridine (2 mL). The reaction was heated at 80 C. for 20 h. After cooling to room temperature, 30 mL of cold water was added. The solid formed was collected by filtration, washed with ammonium hydroxide and water, and dried under vacuum to give 1-(4-fluorophenyl)-3-nitropyridin-2(1H)-one (610 mg, 87% yield) as a solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6332-56-5, 3-Nitropyridin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Bristol-Myers Squibb Company; US2007/78136; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem