Analyzing the synthesis route of 6419-36-9

With the rapid development of chemical substances, we look forward to future research findings about 6419-36-9.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6419-36-9, name is 2-(Pyridin-3-yl)acetic acid hydrochloride, molecular formula is C7H8ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. SDS of cas: 6419-36-9

87 g 3-pyridineacetic acid hydrochloride (500 mmole) was suspended in 225 g chlorobenzene together with 103 g phosphorous trichloride (750 mmole) and heated to 50C for one hour to produce an opaque, 2 phase liquid system containing the acid chloride of 3- pyridineacetic acid.

With the rapid development of chemical substances, we look forward to future research findings about 6419-36-9.

Reference:
Patent; SANDOZ A/S; WO2008/58722; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem