Electric Literature of 65147-89-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.65147-89-9, name is 6-Bromo-2-phenyl-1H-imidazo[4,5-b]pyridine, molecular formula is C12H8BrN3, molecular weight is 274.12, as common compound, the synthetic route is as follows.
Example 223 Under an argon stream, a mixture of 6-bromo-2-phenyl-1H-imidazo[4,5-b]pyridine (Compound of Reference Example 3) (90 mg), phenylboric acid (104 mg), tetrakis(triphenylphosphine)palladium(0) (38 mg), 2 M sodium carbonate (0.82 ml) and tetrahydrofuran (3.3 ml) was stirred at 85C for 24 hours.. The mixture was distributed into ethyl acetate – tetrahydrofuran (3: 1, v/v) and water.. The organic layer was washed with water and dried over MgSO4, and the solvent was distilled off under reduced pressure.. The residue was subjected to silica gel column chromatography, and the fraction eluted with ethyl acetate – chloroform – hexane (1: 1: 4, v/v) was concentrated under reduced pressure.. The resulting crystals were collected by filtration to obtain 2,6-diphenyl-1H-imidazo[4,5-b]pyridine (20 mg, 22 %).. The crystals were recrystallized from chloroform – methanol. HPLC (220 nm) Purity 97 % (Retention time 2.78 minutes) MS (ESI+, m/e) 272 (M+1)
Statistics shows that 65147-89-9 is playing an increasingly important role. we look forward to future research findings about 6-Bromo-2-phenyl-1H-imidazo[4,5-b]pyridine.
Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1460067; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem