Reference of 94220-38-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, molecular formula is C7H6ClN3, molecular weight is 167.5956, as common compound, the synthetic route is as follows.
EXAMPLE 6 7-[3-Dimethylaminopropylamino]-5-methyl-1H-pyrazolo[4,3-b]pyridine (E6) STR20 The title compound was prepared from 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) and 3-dimethylaminopropylamine by the method given in Example 2. On neutralization of the thus formed hydrochloride salt a clear solution was produced. After freeze drying, purification was carried out on Dowex 50W as described in Example 4, followed by crystallization from ethyl acetate to give the title compound as a white crystalline solid, m.p. 112-117. delta(DMSO-d6) 1.55-2.0 (2H,m), 2.23 (3H,s), 2.30-2.55 (2H,m), 3.1-3.5 (2H,m), 6.25 (1H,s), 6.72 (1H,br.t, J=4 Hz), 7.94 (1H,s).
The chemical industry reduces the impact on the environment during synthesis 94220-38-9, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Beecham Group p.l.c.; US4670432; (1987); A;,
Pyridine – Wikipedia,
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