Adding a certain compound to certain chemical reactions, such as: 72587-18-9, 2-Chloro-5-(trifluoromethyl)pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 72587-18-9, blongs to pyridine-derivatives compound. Product Details of 72587-18-9
A 1 00-mL round bottom flask equipped with a magnetic stirrer was charged with 2-chloro-5- (trifluoromethyl)pyridine-3 -amine (1.0 g, 5.1 mmol), CH2C12 (15 mL), TEA (1.42 ml, 10.2 mmol). The reaction mixture was cooled under ice-bath and chloroacetyl chloride (0.81 ml, 10.2 mmol) was slowly added. The reaction mixture was stirred at room temperature for 2 hours. The sovent was removed under vacuum. The residue was purified by column chromatography using 20% EtOAc/hexane to afford the desired product as off-white solid (1.22 g, 88% yield). ). ?H NMR (300 MHz, CDC13) & 9.05 (s, 2H), 8.44 (s, 1H), 4.27 (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,72587-18-9, its application will become more common.
Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; TAXIS PHARMACEUTICALS, INC.; LAVOIE, Edmond J.; PARHI, Ajit; PILCH, Daniel S.; ZHANG, Yongzheng; KAUL, Malvika; WO2014/74932; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem