Reference of 7477-10-3 , The common heterocyclic compound, 7477-10-3, name is 6-Chloro-5-nitronicotinic acid, molecular formula is C6H3ClN2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A solution of compound 4 and different primary and secondary amines were stirred at rt for 1h, followed by extraction with EtOAc. The extract was then washed with 1N HCl, water, and brine, dried over Na2SO4, and evaporated in vacuo. The residue was purified by column chromatography (hexane/EtOAc=2:1) to give product 6 as a solid. 4.2.4.3 6-(Benzylethylamino)-5-nitronicotinic acid (6c) Procedure A was used with compound 5 (405 mg, 2.0 mmol) and benzyl-ethyl-amine (540 mg, 4.0 mmol) to afford product 6c as a yellow solid (428 mg, 71%). 1H NMR (300 MHz, CDCl3) delta: 8.93 (s, 1H), 8.65 (s, 1H), 7.32-7.21 (m, 5H), 4.85 (s, 2H), 3.48 (q, J = 6.9 Hz, 2H), 1.22 (t, J = 6.9 Hz, 3H). ESI-MS: m/z (300, MH-).
The synthetic route of 7477-10-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhao, Chao; Yang, Su Hui; Khadka, Daulat Bikram; Jin, Yifeng; Lee, Kyung-Tae; Cho, Won-Jea; Bioorganic and Medicinal Chemistry; vol. 23; 5; (2015); p. 985 – 995;,
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