Electric Literature of 785762-99-4 ,Some common heterocyclic compound, 785762-99-4, molecular formula is C8H6F3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(3) To a 250 ml single-mouth bottle, 3.5 g (0.094 mol, 1.0 eq) of sodium hydroxide and 18 ml of water (1 v/w) were added, and the mixture was stirred and dissolved. compound 785762-99-4 18 g (0.094 mol, 1.0 eq) was added to the system and the mixture was dissolved. After stirring at 25 C for 0.5 h, the reaction solution was concentrated. A pale yellow solid powder was obtained in a yield of 90.7%. The nuclear magnetic data is as follows:
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 785762-99-4, 2-(5-(Trifluoromethyl)pyridin-2-yl)acetic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Hunan Huateng Pharmaceutical Co., Ltd.; Chen Min; (6 pag.)CN108997202; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem