Reference of 78686-83-6, Adding some certain compound to certain chemical reactions, such as: 78686-83-6, name is Methyl 2-chloro-5-iodonicotinate,molecular formula is C7H5ClINO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 78686-83-6.
Methyl 6-chloro-2′-fluoro-5′-methyl-3,3′-bipyridine-5-carboxylate (11-2)To a solution of methyl 2-chloro-5-iodonicotonate (11-1, 0.25 g, 0.84 mmol, 1.0 equiv) in dimethylformamide (5.6 mL) at 25 C. was added 2-fluoro-5-methyl-3-(tributylstannyl)pyridine (0.34 g, 0.84 mmol, 1.0 equiv), cesium fluoride (0.38 g, 2.52 mmol, 3.0 equiv), copper (I) iodide (0.032 g, 0.17 mmol, 0.2 equiv), and tetrakis(triphenylphosphine)-palladium(0) (0.097 g, 0.084 mmol, 0.1 equiv) and the system was heated to 125 C. for 5 minutes in a microwave reactor. The reaction mixture was cooled and diluted with ethyl acetate (30 mL) and the reaction mixture was filtered through a pad of celite. The reaction mixture was washed with water (3¡Á20 mL) and brine (1¡Á10 mL), dried over magnesium sulfate and concentrated. The residue was purified via normal phase chromatography (0 to 65% EtOAc in hexanes, silica) to afford the desired product (11-2) as a solid after concentration. ESI+MS [M+H]+C13H10ClFN2O2 calc’d 281.0. found 281.0.
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Reference:
Patent; Coleman, Paul J.; Mereer, Swati P.; Reger, Thomas S.; Rocker, Anthony J.; US2010/35931; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem