Analyzing the synthesis route of 790696-96-7

According to the analysis of related databases, 790696-96-7, the application of this compound in the production field has become more and more popular.

Related Products of 790696-96-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 790696-96-7, name is 2-chloro-3-methylisonicotinaldehyde, molecular formula is C7H6ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(2-Chloro-3-methylpyridin-4-ylmethyl)-cyclopropylamine (Q) A sol. of aldehyde P (4.70 g, 30.2 mmol) and cyclopropylamine (4.20 ml, 60.4 mmol) in MeOH (65 mL) was stirred at rt for 4 h. NaBH4 (1.55 g, 39.2 mmol) was added and the mixture was stirred at rt for 12 h. Water and subsequently aq. 1M NaOH were added, and the solvents were partially removed under reduced pressure. The water phase was extracted with CHUCK (2x). The combined org. extracts were dried over MgS04, filtered, and the solvents were removed under reduced pressure. Purification of the crude by FC yielded the title compound (4.66 g, 79%). LC-MS: RT = 0.43 min; ES+ =197. 1.

According to the analysis of related databases, 790696-96-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2005/54243; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem