Reference of 80194-68-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 80194-68-9, name is 3-Chloro-5-(trifluoromethyl)picolinic acid. A new synthetic method of this compound is introduced below.
(1) Add 1 g (1 mmol) of 3-chloro-5-trifluoromethylpicolinic acid and 5 ml of a solvent to a 50 ml single-neck round bottom flask,Add a few drops of the DMF mixture and stir for 10 min.Slowly add a mixture of 0.675 g (1.2 mmol) of oxalyl chloride and DCM. After the dropwise addition, stir at room temperature for 3 h and stop the reaction.The system was spin-dried to obtain intermediate 2;
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,80194-68-9, its application will become more common.
Reference:
Patent; Guizhou University; Xu Fangzhou; Wu Jian; Luo Dexia; Guo Shengxin; He Feng; Zhang Renfeng; Chen Shunhong; (29 pag.)CN110526863; (2019); A;,
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