Application of 824-51-1, Adding some certain compound to certain chemical reactions, such as: 824-51-1, name is 6-Methyl-1H-pyrrolo[2,3-b]pyridine,molecular formula is C8H8N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 824-51-1.
To a solution of 6-methyl-1H-pyrrolo[2,3-b]pyridine (500 mg) in dichloroethane (6 mL) were added aluminumchloride (1.09 g) and acetyl chloride (0.40 mL), and then the mixture was stirred at room temperature for 1.5hours. The reaction solution was poured into aqueous saturated sodium hydrogen carbonate solution, andextracted with chloroform. The organic layer was washed with saturated saline, dried over magnesium sulfate,and then concentrated under reduced pressure. The resulting residue was triturated with isopropyl ether to give1-(6-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone [REx(8-1)] (481 mg) as a yellow powder.APCI-MS m/z: 175[M+H]+.
According to the analysis of related databases, 824-51-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; Shanghai Pharmaceuticals Holding Co., Ltd.; IIJIMA, Toru; SUGAMA, Hiroshi; KAWAGUCHI, Takayuki; SHEN, Jingkang; XIA, Guangxin; XIE, Jianshu; EP2687518; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem