Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 84249-14-9, name is 2-Amino-4-bromopyridine. A new synthetic method of this compound is introduced below., name: 2-Amino-4-bromopyridine
4-Phenyl-2-pyridinamine Phenylboronic acid (141 mg, 1.156 mmol), 4-bromo-2-pyridinamine (200 mg, 1.156 mmol) and PdCl2(dppf)CH2Cl2 adduct (94 mg, 0.116 mmol) were collected and suspended in 1,2-dimethoxyethane (3 ml) and 1M aq sodium carbonate solution (3.47 ml, 3.47 mmol). The resulting mixture was stirred at 90 C. for 5 hours then it was cooled to r.t. and filtered over a celite pad washing with DCM. The solvent was evaporated (in vacuo) and the crude was purified by silica gel chromatography (Biotage 40M column) and eluding in gradient with 0%-10% MeOHDCM to afford the title compound (195 mg, 1.146 mmol, 99%). 1H NMR (400 MHz, CDCl3): delta 4.49 (dd, 2H), 6.69-6.78 (m, 1H), 6.90 (dd, 1H), 7.39-7.52 (m, 3H), 7.56-7.68 (m, 2H), 8.10-8.17 (m, 1H); UPLC-MS: 0.42 min, 171 [M+H]+.
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Reference:
Patent; Biagetti, Matteo; Contini, Stefania Anna; Genski, Thorsten; Guery, Sebastien; Leslie, Colin Philip; Mazzali, Angelica; Pizzi, Domenica Antonia; Sabbatini, Fabio Maria; Seri, Catia; US2009/203705; (2009); A1;,
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