Reference of 866546-07-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 866546-07-8 as follows.
[94] Step 5. N-(3 -((5-Chloro- 1 Eta-rhonuetachi)1omicronGamma2.3 -blpyridin-3 -yl)(hvdroxy)-methyl)-2.4- difluorophenyl)- 1.1.2.2.3.3.3 -d7-propane- 1 -sulfonamide (24):; To a solution offormylsulfonamide 23 (50.0 mg, 0.185 mmol) in MeOH/Water 1 : 1 (1 mL) was added 5- chloroazaindole 6a(i) (30.0 mg, 0.196 mmol, Adesis, Inc.) followed by K2CO3 (171 mg, 1.24 mmol). The resulting solution stirred at room temperature for 3 days then was neutralized to pH 7 with 4N HC1 and extracted with EtO Ac (3 x 50 mL). The organic layers were combined, washed with water, dried (Na2S04), filtered and concentrated under reduced pressure to afford azaindole 24 (60 mg, 77%) as a tan solid which was used without further purification. MS (ESI) 421.0 [(M – H) “].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,866546-07-8, its application will become more common.
Reference:
Patent; CONCERT PHARMACEUTICALS INC.; TUNG, Roger; MASSE, Craig E.; SILVERMAN, I. Robert; WO2011/60216; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem