Electric Literature of 870997-81-2, Adding some certain compound to certain chemical reactions, such as: 870997-81-2, name is 3-Amino-2-methoxy-4-pyridinecarboxylic acid,molecular formula is C7H8N2O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870997-81-2.
To a solution of 3-amino-2-methoxyisonicotinic acid (5.0 g, 29.7 mmol, Ark Pharm, Inc. – AK-39940) in dichloromethane (45 mL) and methanol (5 mL) at 0C was added trimethylsilyldiazomethane as 2.0M solution in hexanes (44.6 mL, 89.2 mmol) . After addition was complete, the reaction was quenched with water. The reaction mixture was extracted with dichloromethane. The organics were dried over sodium sulfate, filtered and concentrated down under reduced pressure to yield the compound 1a. 1H NMR (400 MHz, DMSO-d6) delta 7.29 (d, J = 5.6 Hz, 1 H), 7.1 1 (d, J = 5.6 Hz, 1 H), 6.45 (bs, 2H), 3.89 (s, 3H), 3.80 (s, 3H). LCMS (m/z) 183.0 [M+H], Tr = 1.21 min (LCMS method 1 ).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 870997-81-2, 3-Amino-2-methoxy-4-pyridinecarboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GILEAD SCIENCES, INC.; INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE AS CR, V.V.I.; JANSA, Petr; KVASNICA, Miroslav; MACKMAN, Richard, L.; (79 pag.)WO2016/105532; (2016); A1;,
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