Synthetic Route of 872355-55-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 872355-55-0 as follows.
6-Methyl-lH-pyrrolo[2,3-b]pyridine-5-carboxylic acid (0.65 g) and 4-fluorobenzyl- 2S,5R-dimethyl piperazine (0.82 g) were dissolved in dry DMF (10 mL) and TBTU (1.18 g) was added followed by triethylamine(l .54 mL). The mixture was stirred for 5 h, whereupon it was poured into water and the solid thus separated was filtered and dried. The crude was purified by silica gel chromatography using ethyl acetate as a solvent (Yield: 0.87 g, Rf. 0.767min, Condition B, M+H+: 380).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,872355-55-0, its application will become more common.
Reference:
Patent; SCIOS, INC.; WO2006/112828; (2006); A1;,
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