Reference of 880870-13-3, Adding some certain compound to certain chemical reactions, such as: 880870-13-3, name is 5-Bromo-2-chloro-4-methoxypyridine,molecular formula is C6H5BrClNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 880870-13-3.
The compound (2.82 g, 12.68 mmol) obtained in Step 8 was dissolved in tetrahydrofuran (10 ml) and, under an argon atmosphere, dichlorobis(triphenylphosphine) palladium(II) (445 mg, 0.63 mmol) and 1 M 3-chloro-2-fluorobenzylzinc bromide tetrahydrofuran solution (17.75 ml, 17.75 mmol) were added dropwise, and the mixture was heated under reflux at 80 C. for 2 hr. A saturated aqueous ammonium chloride solution was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous ammonium chloride solution and saturated brine, and dried over sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the residue was purified by silica gel chromatography (hexane:ethyl acetate=5:1) to give the object product as a white solid (2.19 g, yield 60%). 1H NMR(CDCl3 300 MHz) (delta) ppm: 3.86 (3H, s), 3.91 (2H, s), 6.79 (1H, s), 6.94-7.01 (2H, m), 7.23-7.28 (1H, m), 8.03 (1H, s)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 880870-13-3, 5-Bromo-2-chloro-4-methoxypyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Satoh, Motohide; Aramaki, Hisateru; Nakamura, Hiroshi; Inoue, Masafumi; Kawakami, Hiroshi; Shinkai, Hisashi; Matsuzaki, Yuji; Yamataka, Kazunobu; US2006/84665; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem