Adding a certain compound to certain chemical reactions, such as: 884494-82-0, 5-Fluoro-2-methoxynicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 884494-82-0, blongs to pyridine-derivatives compound. Formula: C7H6FNO3
[0429] A solution of 2-(4-(4-fluorobenzd)piperazin-l-yl)-6-methylpyridin-3-arnine (72 mg, 0.240 rnmol), 5-fluoro-2-methoxynicotinic acid (123 mg, 0.719 mmol), HATU (273 mg, 0.719 mmol) and DIPEA (167 muEpsilon, 0,959 mmol) in DMF (1199 muEpsilon) was stirred on a hot plate at 80C overnight. The reaction mixture was filtered through a Millipore filter, diluted with DMF and MeOH and purified by HPLC (Sliimadzu) eluting with a gradient of ACN in water (basic mode) to give the title compound as a pale brown solid (64.6 mg, 59.4%). NMR (400 MHz, CDCb) delta ppm 2,46 (s, 3 H), 2.64 (br s, 4 H), 3.14 (br s, 4 H), 3,60 (br s, 2 H), 4.16 (s, 3 H), 6.91 (d, J=8,08 Hz, 1 H), 7.03 (t, /=8.59 Hz, 2 H), 7.32 (br s, 2 H), 8.17 (d, J=3.28 Hz, 1 H), 8.36 (dd, (1382) -8.08 Hz, 1 H), 10.31 (br s, 1 H); ESI-MS m/z j M H | ‘ 454.3. (1383) (1384) [0430] The preparation of Example 100 yielded the title compound as a des-methyl side product which was recovered as an orange solid (12.4 mg, 11.8%). NMR (400 MHz, CDCb) delta ppm 2.40 – 2.47 (m, 3 H), 2.82 (br s, 4 H), 3,27 (br s, 6 H), 6,89 id. ./ 8.08 Hz, 1 H), 7,03 (t, ./ 7.96 Hz, 2 H), 7.42 (br s, 2 H), 7,55 (br s, 1 H), 8,53 – 8.64 (m, 2 H), 11.69 – 11,88 (m, 1 H); ESI-MS m/z [M+H]” 440.3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,884494-82-0, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; GREEN, Jason; HOPKINS, Maria; JONES, Benjamin; KIRYANOV, Andre A.; KUEHLER, Jon; MONENSCHEIN, Holger; MURPHY, Sean; NIXEY, Thomas; SUN, Huikai; (300 pag.)WO2018/183145; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem